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Publications and Presentations

2023

Original Research Publication - 16 December 2023

Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

Michael J. Tolentino, MD, Andrew J. Tolentino, BS, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD

Pharmaceuticals - MDPI

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Original Research Publication - 16 November 2023

PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration

Anitha Krishnan, PhD, Victor G. Sendra, PhD, Diyan Patel, MS, Amit Lad, PhD, Michelle K. Greene, PhD, Peter Smyth, PhD, Samantha A. Gallaher, Úna M. Herron, PhD, Christopher J. Scott, PhD, Mohamed Genead, MD, Michael J. Tolentino, MD

Frontiers in Immunology

Edited by: Bebhinn Treanor

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Drug Discovery & Lead Optimization, San Francisco, CA, United States Presentation - November 2023

Developing Immunomodulatory Sialic Acid Mimetic Nanoparticles Therapeutics Utilizing High Affinity Ligands

Michael J. Tolentino, MD

Eyecelerator, San Francisco, CA, United States Presentation - November 2023

Using Nature’s Design but Better… Pioneering a New Wave of Therapeutics Using Glycoimmunology

Mohamed Genead, MD

Glyco in Biotechnology Satellite Meeting, Big Island, HI, United States Presentation - November 2023

Harness the Power of Glycobiology and Nanotechnology to Address Unmet Medical Need

Anitha Krishnan, PhD

Original Research Publication - 27 October 2023

SIGLECs the Main Self-Pattern Recognition Receptors of the Immune System. A Promising Target for Inflammatory Modulation

Andrew J. Tolentino, BS, Michael J. Tolentino, MD, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD

American Journal of Biomedical Science & Research

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Euretina Innovation Summit, Amsterdam, Netherlands Presentation - October 2023

Innovation in Treatment Modalities

Mohamed Genead, MD - Panelist

Ophthalmology Futures Forum, Amsterdam, Netherlands Presentation - October 2023

Glycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy

Tarek Hassan, MD

EURETINA, Amsterdam, Netherlands Presentation - October 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles

Baruch D. Kuppermann, MD, PhD

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Retina Society, New York, NY, United States Presentation - October 2023

Modulation of Macrophages and Complement Dysfunction in Geographic Atrophy From Macular Degeneration Utilizing Sialic-acid Coated Nanoparticles

David Chow, MD

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ASRS, Seattle, WA, United States Presentation - July 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles

Carl D. Regillo, MD, FACS, FASRS

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Publication - July/August 2023

Glycoimmune Therapy as a Novel Treatment Approach for Geographic Atrophy

Sophie J. Bakri, MD, MBA, Jeffrey S. Heier, MD, Arshad M. Khanani, MD, Ma, FASRS, Baruch D. Kuppermann, MD, PhD, Carl D. Regillo, MD, FACS, FASRS, Peter K. Kaiser, MD, FASRS

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Retinal Imaging Biomarkers & Endpoints Summit (2023), Boston, MA, United States Presentation - June 2023

Navigating the Expanding Availability of Retinal Imaging Technologies to Transform your Clinical Pipeline

David Callanan, MD

ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative Age-Related Macular Degeneration Utilizing a Sialic-acid Coated Nanoparticle.

Baruch D. Kuppermann, MD, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD

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ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Modulation of Retinal Inflammatory Macrophages by Polysialic-Acid Coated Nanoparticles as Novel Mechanism for Nonexudative AMD Treatment.

Anitha Krishnan, PhD, , Victor G. Sendra, PhD, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD

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ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Targeting Self-Recognition Pattern Receptors on Retina Immune Cells with an Engineered Glycan-coated Nanoparticle as a Novel Therapy for Nonexudative AMD.

, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD

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CTS, Salt Lake City, UT, United States Presentation - March 2023

Glycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy

Tarek Hassan, MD

Retinal Detachment Society Meeting (2023), Snowmass, CO, United States. Presentation - March 2023

Glyco-Immunology: Attacking Dry AMD in a Different Way…

Tarek Hassan, MD

Macula Society (2023), Miami, FL, United States Presentation - February 2023

Glyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.

Robert Avery MD

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8th Cairo Retina Meeting (2023), Cairo, Egypt Presentation - January 2023

Glyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.

Tarek Hassan, MD

3rd Dry AMD Summit (2022), Boston, MA, United States Presentation - November 2022

New Wave of Glyco-Immuno Therapeutics Focus on Ophthalmology.

David Callanan, MD

Publication - 31 October 2022

Investigational drugs in clinical trials for macular degeneration

Michael J. Tolentino, MD, Andrew J. Tolentino, BS

1067-1085, DOI: 10.1080/13543784.2022.2113375

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Retina Society (2022) Pasadena, CA, United States Presentation - October 2022

Modulation of Innate Immunity & Complement Dysfunction in Patients with Geographic Atrophy Utilizing a Novel Glyco-Engineered Therapeutic Nano-Technology.

Michael Singer, MD

OIS (2022), San Diego, CA, United States Presentation - July 2022

Glyco-Engineered Coated Nanoparticles A Novel Therapeutic for the treatment of Dry AMD.

Michael J. Tolentino, MD

CTS (2022), Incline Village, NV, United States Presentation - June 2022

Modulation of Innate Immune & Complement Dysfunction in patients with Geographic Atrophy utilizing a novel glyco-engineered therapeutic nano-technology.

Peter K. Kaiser, MD, FASRS, David Callanan, MD, Michael J. Tolentino, MD, Derek Kunimoto, MD, Mohamed Genead, MD, Anitha Krishnan, PhD

ARVO (2022), Denver, CO, United States Presentation - May 2022

Anti-inflammatory role of a glycan-coated nanoparticle in modulating macrophages and complement in non-exudative AMD.

Anitha Krishnan, PhD; Rajesh Shinde, PhD; Derek Kunimoto, MD; Michael J. Tolentino, MD; Mohamed Genead, MD

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Publication - April 2021

Targeting Innate Immune Activity in Age-Related Macular Degeneration Promising candidate molecules are in later stages of development.

Carl D. Regillo, MD, FACS, FASRS; Jeffrey S. Heier, MD

Retinal Physician, Volume: 18, Issue: April 2021, page(s): 42-45

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